TLR4 participates in the transmission of ethanol-induced neuroinflammation via astrocyte-derived extracellular vesicles.

Francesc IbáñezJorge MontesinosJuan R Ureña-PeraltaConsuelo GuerriMaría Pascual

Published in: Journal of neuroinflammation (2019)

These results suggest that astrocyte-derived EVs could act as cellular transmitters of inflammation signaling by spreading and amplifying the neuroinflammatory response induced by ethanol through TLR4 activation.

Keyphrases

toll like receptor
inflammatory response
immune response
oxidative stress
lipopolysaccharide induced
diabetic rats
high glucose
traumatic brain injury
lps induced
nuclear factor
cognitive impairment
brain injury
endothelial cells
cerebral ischemia