TLR4 participates in the transmission of ethanol-induced neuroinflammation via astrocyte-derived extracellular vesicles.
Francesc IbáñezJorge MontesinosJuan R Ureña-PeraltaConsuelo GuerriMaría PascualPublished in: Journal of neuroinflammation (2019)
These results suggest that astrocyte-derived EVs could act as cellular transmitters of inflammation signaling by spreading and amplifying the neuroinflammatory response induced by ethanol through TLR4 activation.