Adverse Drug Reaction Onsets in Uganda's VigiBase®: Delayed International Visibility, Data Quality and Illustrative Signal Detection Analyses.
Ronald KigubaHelen B NdagijeVictoria NambasaSheila M BirdPublished in: Pharmaceutical medicine (2018)
Barely one ADR onset per day was registered on VigiBase® from those submitted to Uganda's National Pharmacovigilance Centre during 2012-2014; only one in six was from patients aged < 20 years. Paediatric pharmacovigilance requires more emphasis in Uganda. Delays from reported ADR onset to international visibility on VigiBase® need to reduce dramatically. Quality assurance revealed rectifiable data entry deficits. Signal detection performed well for patients receiving ART.
Keyphrases
- adverse drug
- electronic health record
- emergency department
- end stage renal disease
- drug induced
- ejection fraction
- newly diagnosed
- loop mediated isothermal amplification
- chronic kidney disease
- traumatic brain injury
- real time pcr
- prognostic factors
- big data
- single cell
- hiv infected
- patient reported outcomes
- deep learning