Stroke-Induced Neurological Dysfunction in Aged Mice Is Attenuated by Preconditioning with Young Sca-1+ Stem Cells.

Lukasz WlodarekFaisal J AlibhaiJun WuShu-Hong LiRen-Ke Li

Published in: Stem cells (Dayton, Ohio) (2022)

This study provides a proof-of-principle demonstrating that young BM Sca-1+ cells play a pivotal role in reversing stroke-induced cognitive impairments and protect the aged brain against secondary injury by attenuating the host cell response to injury.

Keyphrases

stem cells
cerebral ischemia
high glucose
atrial fibrillation
diabetic rats
induced apoptosis
oxidative stress
cell therapy
middle aged
drug induced
endothelial cells
ischemia reperfusion injury
subarachnoid hemorrhage
brain injury
functional connectivity