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Single-digit-micrometer-resolution continuous liquid interface production.

Kaiwen HsiaoBrian J LeeTim SamuelsenGabriel LipkowitzJason M KronenfeldDan IlynAudrey ShihMaria T DulayLee TateEric S G ShaqfehJoseph M DeSimone
Published in: Science advances (2022)
To date, a compromise between resolution and print speed has rendered most high-resolution additive manufacturing technologies unscalable with limited applications. By combining a reduction lens optics system for single-digit-micrometer resolution, an in-line camera system for contrast-based sharpness optimization, and continuous liquid interface production (CLIP) technology for high scalability, we introduce a single-digit-micrometer-resolution CLIP-based 3D printer that can create millimeter-scale 3D prints with single-digit-micrometer-resolution features in just a few minutes. A simulation model is developed in parallel to probe the fundamental governing principles in optics, chemical kinetics, and mass transport in the 3D printing process. A print strategy with tunable parameters informed by the simulation model is adopted to achieve both the optimal resolution and the maximum print speed. Together, the high-resolution 3D CLIP printer has opened the door to various applications including, but not limited to, biomedical, MEMS, and microelectronics.
Keyphrases
  • high resolution
  • single molecule
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  • mass spectrometry
  • magnetic resonance imaging
  • computed tomography
  • quantum dots
  • endoscopic submucosal dissection
  • convolutional neural network