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Epigallocatechin-3-gallate suppresses hemin-aggravated colon carcinogenesis through Nrf2-inhibited mitochondrial reactive oxygen species accumulation.

Ju-Hyung SeokDae Hyun KimHye Jih KimHang Hyo JoEun Young KimJae-Hwang JeongYoung Seok ParkSang-Hun LeeDae Joong KimSang-Yoon NamBeom Jun LeeHyun Jik Lee
Published in: Journal of veterinary science (2022)
We demonstrated that EGCG reduced hemin-induced proliferation and colon carcinogenesis through Nrf2-inhibited mitochondrial ROS accumulation.
Keyphrases
  • oxidative stress
  • reactive oxygen species
  • diabetic rats
  • dna damage
  • signaling pathway
  • high glucose
  • cell death
  • drug induced