Login / Signup

Self-assembling small-molecule adjuvants as antigen nano-carriers.

Shuyu JinShao-Hua ZhuoYasushi TakemotoYan-Mei LiMotonari Uesugi
Published in: Chemical communications (Cambridge, England) (2022)
The effective co-delivery of antigens and immune potentiators (adjuvants) and the high degree of antigen presentation have been two major challenges in the development of subunit vaccines. Here, we address these issues by conjugating peptide antigens with cholicamide, a self-assembling small molecule adjuvant. Co-assemblies of the conjugates and cholicamide achieved high levels of both cytokine induction and MHC class II peptide presentation.
Keyphrases
  • small molecule
  • protein protein
  • dendritic cells
  • case report
  • early stage
  • protein kinase