Restoring erectile function by combined treatment with JNK inhibitor and HDAC inhibitor in a rat model of cavernous nerve injury.

Jeong Hoon Lee Min Chul Cho Hwancheol Son Soo Woong Kim

Published in: Andrology (2022)

The combined administration of JNKi and HDACi during the acute phase after CNCI in rats can preserve ED by suppressing cavernosal fibrosis and apoptosis by normalizing the HDAC/TGF-β and JNK pathways.

Keyphrases

cell death
signaling pathway
induced apoptosis
histone deacetylase
emergency department
endoplasmic reticulum stress
oxidative stress
cell cycle arrest
transforming growth factor
peripheral nerve
epithelial mesenchymal transition
benign prostatic hyperplasia