The role of revision sinus surgery in the initiation of dupilumab therapy: A real-world study of molecular and cellular features.

Abigail GaffarAbdul Rahman AleneziKathleen M KellyHeather M KulagaHsin-Tzu KengAmy SmithAndrew P Lane

Published in: International forum of allergy & rhinology (2024)

A persistent type 2 endotype signature exists in recalcitrant chronic rhinosinusitis with nasal polyps mucosa on dupilumab. Revision sinus surgery immediately prior to dupilumab reduces long-term interleukin (IL)-4/IL-13 tissue mRNA. Pre-dupilumab revision surgery is associated with reduced tissue eosinophils and GATA-3+ cells.

Keyphrases

atopic dermatitis
chronic rhinosinusitis
minimally invasive
total knee arthroplasty
coronary artery bypass
total hip arthroplasty
surgical site infection
induced apoptosis
transcription factor
cell cycle arrest
stem cells
oxidative stress
cell proliferation
mesenchymal stem cells
cell therapy