Neurofilament light chain in the vitreous humor of the eye.

Manju L SubramanianViha VigJaeyoon ChungMarissa G FiorelloWeiming XiaHenrik ZetterbergKaj BlennowMadeleine ZetterbergFarah ShareefNicole H SiegelSteven NessGyungah R JunThor D Stein

Published in: Alzheimer's research & therapy (2020)

NfL is detectable in the vitreous humor of the eye and significantly associated with amyloid beta, t-tau, and select inflammatory and vascular proteins in the vitreous. Additionally, NfL was not associated with patients' clinical eye condition. Our results serve as a foundation for further investigation of NfL in the ocular fluids to inform us about the potential utility of its presence in the eye.

Keyphrases

newly diagnosed
cerebrospinal fluid
oxidative stress
chronic kidney disease
end stage renal disease
ejection fraction
human health
prognostic factors
patient reported outcomes
patient reported