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RNA modification of an RNA modifier prevents self-RNA sensing.

Daltry L SniderStacy M Horner
Published in: PLoS biology (2021)
A new study in PLOS Biology finds that interferon (IFN)-induced adenosine deaminase acting on RNA 1 (ADAR1) mRNA is N6-methyladenosine (m6A) modified to promote its translation, enabling ADAR1 to modify self-double-stranded RNAs (dsRNAs) generated during the IFN response and preventing activation of the melanoma differentiation-associated protein 5 (MDA5)-mediated host antiviral response.
Keyphrases
  • dendritic cells
  • nucleic acid
  • immune response
  • binding protein
  • mouse model
  • oxidative stress
  • breast cancer cells
  • cell death
  • cell cycle arrest
  • basal cell carcinoma