Reduced Nephron Endowment in Six2-TGCtg Mice Is Due to Six3 Misexpression by Aberrant Enhancer-Promoter Interactions in the Transgene.

Alison J Perl Han Liu Matthew R Hass Nirpesh Adhikari Praneet Chaturvedi Yueh-Chiang Hu Rulang Jiang Yaping Liu Raphael Kopan

Published in: Journal of the American Society of Nephrology : JASN (2024)

These findings broadly demonstrate the utility of Hi-C data in mapping transgene integration sites and architecture. Data from genetic and biochemical studies together suggest that in Six2TGC kidneys, SIX3 interferes with SIX2 function in nephron progenitor cell renewal through its C-terminal domain.

Keyphrases

electronic health record
transcription factor
big data
high resolution
gene expression
genome wide
high fat diet induced
machine learning
type diabetes
data analysis
binding protein
skeletal muscle
copy number
artificial intelligence
adipose tissue
metabolic syndrome
wild type