Downregulation of the LncRNA MEG3 Promotes Osteogenic Differentiation of BMSCs and Bone Repairing by Activating Wnt/β-Catenin Signaling Pathway.

Juan LiuXin QiXiao-Hong WangHong-Sheng MiaoZi-Chao XueLe-Le ZhangSan-Hu ZhaoLiang-Hao WuGuo-Yi GaoMei-Qing LouCheng-Qing Yi

Published in: Journal of clinical medicine (2022)

Our study reveals the important role of MEG3 during osteogenic differentiation and bone regeneration. Thus, MEG3 engineered BMSCs may be effective potential therapeutic targets for skull defects.

Keyphrases

bone regeneration
cell proliferation
signaling pathway
resting state
mesenchymal stem cells
stem cells
bone marrow
functional connectivity
bone mineral density
long non coding rna
risk assessment
human health
climate change
bone loss