Does in vitro hemolysis affect measurements of plasma apixaban concentration by UPLC-MS and anti-Xa assay?

Henriette Røed-UndlienNina Haagenrud SchultzErik Koldberg AmundsenBirgit M WollmannEspen MoldenRupali R AkerkarJohannes Lagethon Bjørnstad

Published in: International journal of laboratory hematology (2024)

Apixaban concentration measurements by anti-Xa assay and UPLC-MS were not affected by hemolysis to a clinically relevant extent. Furthermore, hemolysis did not lead to hypocoagulability when assessed by thrombin generation.

Keyphrases

mass spectrometry
venous thromboembolism
red blood cell
multiple sclerosis
atrial fibrillation
high throughput
ms ms
simultaneous determination