Brain Tissue Reaction to Deep Brain Stimulation-A Longitudinal Study of DBS in the Goettingen Minipig.
Dariusz OrlowskiAlexandre MichalisAndreas N GludAnders R KorshøjLise M FittingTrine W MikkelsenAndré MercanziniAlain JordanAlain DransartJens C H SørensenPublished in: Neuromodulation : journal of the International Neuromodulation Society (2017)
Tissue reaction was, on average, limited to distance of 500 μm from the lead track. The tissue response after 12 months was weaker than after 6 months confirming that it stabilizes over a time. There was no histological evidence that the stimulated part of the electrode triggered different tissue response than its nonstimulated part.