Tandem Mass Spectrometry-Based Amyloid Typing Using Manual Microdissection and Open-Source Data Processing.
William S PhippsKelly D SmithHan-Yin YangClark M HendersonHannah PflaumMelissa L LerchWilliam E FondrieMichelle A EmrickChristine C WuMichael J MacCossWilliam S NobleAndrew N HoofnaglePublished in: American journal of clinical pathology (2022)
Accurate mass spectrometry-based amyloid typing is possible without laser microdissection. To facilitate entry into solid tissue proteomics, newcomers can leverage manual sampling approaches in combination with Crux Pipeline and related tools.
Keyphrases
- mass spectrometry
- liquid chromatography
- tandem mass spectrometry
- gas chromatography
- high performance liquid chromatography
- ultra high performance liquid chromatography
- high resolution
- high resolution mass spectrometry
- simultaneous determination
- solid phase extraction
- capillary electrophoresis
- genetic diversity
- electronic health record
- big data
- high speed
- ms ms
- deep learning
- data analysis