Enantioselective Total Synthesis of (+)-KB343.
Cheng BiYu WangChi HePhil S BaranPublished in: Journal of the American Chemical Society (2023)
A concise total synthesis of the complex guanidinium toxin KB343 is reported traversing through an unusual sequence of chemoselective transformations and strategic skeletal reorganization. The absolute configuration is confirmed through an enantioselective route, and the structures of all key intermediates and the natural product itself are unassailably confirmed through X-ray crystallographic analysis.