Quantification of total and unbound cefuroxime in plasma by ultra-performance liquid chromatography tandem mass spectrometry in a cohort of critically ill patients with hypoalbuminemia and renal failure.

Joost Johan Van RaaijNoortje J D MabelisKimberly N ShudofskySjoerd D MeenksJos L M L le NoblePaddy Koen Camiel Janssen

Published in: Journal of clinical laboratory analysis (2019)

The method is precise and accurate according to ISO 15189 and within the clinical range of cefuroxime (0.5-100 mg/L). The method was applied in ICU patients and is suitable for TDM on unbound cefuroxime concentrations.

Keyphrases

liquid chromatography tandem mass spectrometry
end stage renal disease
chronic kidney disease
ejection fraction
high resolution
newly diagnosed
intensive care unit
ms ms
peritoneal dialysis
solid phase extraction
patient reported outcomes