Design and Characterization of an Osmotic Pump System for Optimal Feeding and pH Control in E. coli Culture to Increase Biomass.
Saeedeh AbedinJavad RanjbariAzadeh HaeriHossein VahidiHamid Reza MoghimiPublished in: Iranian journal of pharmaceutical research : IJPR (2024)
The use of CPOP, which is capable of controlled release of glucose as a carbon source and sodium carbonate as a pH modifier, can overcome the drawbacks of bolus feeding, such as decreased pH, increased acetate concentration, and low productivity. It has a good potential for commercialization.