Intact HIV Proviruses Persist in the Brain Despite Viral Suppression with ART.
Catherine R CochraneThomas A AngelovichSarah J ByrnesEmily WaringAleks C GuanizoGemma S TrollopeJingling ZhouJudith VueLachlan SeniorEmma WanicekJanna Jamal EddineMatthew J GartnerTrisha A JenkinsPaul R GorryBruce J BrewSharon R LewinJacob D EstesMichael RocheMelissa J ChurchillPublished in: Annals of neurology (2022)
Our results demonstrate the first evidence for an intact, potentially replication competent HIV reservoir in the CNS of virally suppressed PWH. ANN NEUROL 2022;92:532-544.