Rosiglitazone in the thawing medium improves mitochondrial function in stallion spermatozoa through regulating Akt phosphorylation and reduction of caspase 3.

José M Ortiz-RodriguezCarolina Balao da SilvaA Javier Masot Eloy RedondoAntonio GazquezJosé A TapiaCruz GilCristina Ortega-FerrusolaFernando J Peña

Published in: PloS one (2019)

We provide the first evidence that the functionality of frozen stallion spermatozoa can be potentially improved after thawing through the activation of pro survival pathways, providing new clues for improving current sperm biotechnology.

Keyphrases

cell death
signaling pathway
cell proliferation
protein kinase
free survival
oxidative stress