Protein Z and Endothelin-1 genetic polymorphisms in pediatric Egyptian sickle cell disease patients.
Mervat Mamdooh KhorshiedNohair S MohamedRania S HamzaRasha M AliMona K El-GhamrawyPublished in: Journal of clinical laboratory analysis (2017)
Endothelin-1 G5665T polymorphism could be considered as a molecular predictor for pulmonary dysfunction and severe VOC in SCD. Further researches with larger cohorts are recommended to understand the pathophysiology of SCD and to explain the inter-patients' variability of disease severity.