Modeling the therapeutic efficacy of NFκB synthetic decoy oligodeoxynucleotides (ODNs).

Zhipeng WangDavit A PotoyanPeter G Wolynes

Published in: BMC systems biology (2018)

The pharmacokinetics/pharmacodynamics (PK/PD) predicted by the systems-level model should provide quantitative guidance for in-depth translational research of optimizing the thermodynamics/kinetic properties of synthetic decoy ODNs.

Keyphrases

signaling pathway
lps induced
high resolution
optical coherence tomography
oxidative stress
nuclear factor
inflammatory response