ABO genotyping with next-generation sequencing to resolve heterogeneity in donors with serology discrepancies.

Ping Chun WuYin-Hung LinLei Fang TsaiMing Hung ChenPei-Lung ChenShun-Chung Pai

Published in: Transfusion (2018)

This study demonstrated a full coverage of ABO by capture-based panel, phasing analysis with NGS in ABO genotyping resolved heterogeneity with novel allele and microchimerism findings. This approach provided a more precise method for subtyping and thereby leading to safer transfusion.

Keyphrases

single cell
high throughput
genome wide
cardiac surgery
copy number
dna methylation
gene expression
acute kidney injury
affordable care act
kidney transplantation