Aucubin Protects Chondrocytes Against IL-1β-Induced Apoptosis In Vitro And Inhibits Osteoarthritis In Mice Model.
Bo-Wei WangYi JiangZi-Long YaoPei-Sheng ChenBin YuSheng-Nan WangPublished in: Drug design, development and therapy (2019)
Our findings suggest that aucubin has a protective effect on articular cartilage and slowing progression of OA in a mouse model. This protective effect may result from inhibiting chondrocyte apoptosis and excessive ROS production.
Keyphrases
- induced apoptosis
- endoplasmic reticulum stress
- oxidative stress
- signaling pathway
- mouse model
- knee osteoarthritis
- cell death
- dna damage
- rheumatoid arthritis
- cell cycle arrest
- high fat diet induced
- pi k akt
- weight gain
- reactive oxygen species
- extracellular matrix
- type diabetes
- metabolic syndrome
- wild type
- insulin resistance
- physical activity