Severe Acute Respiratory Syndrome Coronavirus 2 Spreads to Lymph Nodes and Strongly Expands CD4+ Effector Memory RA Cells in a Patient With Mild Coronavirus Disease 2019.
Ernesto Roldán-SantiagoAmparo Benito-BerlinchesLaura Martínez-GarcíaCarmen QueredaEulalia Rodríguez-MartínPilar Pérez-ElíasJose María López-PintorPaulette Esperanza Walo-DelgadoAna Moreno-ZamoraJose Ignacio Fernández-VelascoPatricia García-AbellásRubén Ballester-GonzálezLuisa M VillarMaría Jesús Pérez ElíasPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
A woman with mild coronavirus disease 2019 developed cervical adenopathy, being diagnosed of Epstein-Barr virus infectious mononucleosis. We performed fine needle aspiration, and demonstrate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is found in lymph nodes even in mild disease along with a strong expansion of terminally differentiated effector memory CD4+ T cells, a cell population that is practically absent in lymph nodes.
Keyphrases
- respiratory syndrome coronavirus
- lymph node
- coronavirus disease
- epstein barr virus
- sars cov
- fine needle aspiration
- neoadjuvant chemotherapy
- sentinel lymph node
- diffuse large b cell lymphoma
- ultrasound guided
- induced apoptosis
- case report
- regulatory t cells
- dendritic cells
- working memory
- cell cycle arrest
- rheumatoid arthritis
- single cell
- type iii
- cell therapy
- stem cells
- ankylosing spondylitis
- signaling pathway
- cell death
- bone marrow
- disease activity
- endoplasmic reticulum stress
- cell proliferation
- interstitial lung disease
- immune response