Beta-Hydroxybutyrate Suppresses Hepatic Production of the Ghrelin Receptor Antagonist LEAP2.
Stephanie Kjaerulff HolmAnna S HustedLouise J SkovThomas H MorvilleChristoffer A HagemannTina JorsalMorten DallAlexander JakobsenAnders B KleinJonas T TreebakFilip K KnopThue W SchwartzChristoffer ClemmensenBirgitte HolstPublished in: Endocrinology (2022)
From our data, we suggest that LEAP2 is downregulated during different states of energy deprivation in both humans and rodents. Furthermore, we here provide evidence that the ketone body, BHB, which is highly upregulated during fasting metabolism, directly downregulates LEAP2 levels. This may be relevant in ghrelin receptor-induced hunger signaling during energy deprivation.