Observation of Reduced Homeostatic Metabolic Activity and/or Coupling in White Matter Aging.

Valerie C AndersonIan J TaggeXin LiJoseph F QuinnJeffrey A KayeDennis N BourdetteRebecca I SpainLouis P RiccelliManoj K SammiCharles S SpringerWilliam D Rooney

Published in: Journal of neuroimaging : official journal of the American Society of Neuroimaging (2020)

Previous studies have shown that kpo tracks Na+ , K+ -ATPase activity-dependent water exchange at the BBB and likely reflects neurogliovascular unit (NGVU) coupled metabolic activity. The age-related decline in kpo observed here is consistent with compromised NGVU metabolism in older individuals and the dysregulated cellular bioenergetics that accompany normal brain aging.

Keyphrases

white matter
physical activity
blood brain barrier
room temperature
middle aged
case control
functional connectivity
ionic liquid