Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy.
Carmela PassaroQuazim AlayoIsabella De LauraJohn McNultyKorneel GrauwetHirotaka ItoVivek BhaskaranMarco MineoSean E LawlerKhalid ShahMaria C SperanzaWilliam GoinsEric M McLaughlinSoledad FernandezDavid A ReardonGordon J FreemanE Antonio ChioccaHiroshi NakashimaPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
NG34scFvPD-1 treatment induces a durable antitumor response in 2 preclinical mouse models of GBM with evidence for antitumor memory.