MOBP and HIP1 in multiple system atrophy: New α-synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis.

Conceicao BettencourtYasuo MikiIgnazio S PirasRohan de SilvaSandrine C FotiJoshua S TalboomTamas ReveszTammaryn LashleyRobert BalazsEmmanuelle ViréThomas T WarnerMatt J HuentelmanJanice L Holton

Published in: Neuropathology and applied neurobiology (2021)

This study supports a role for DNA methylation in downregulation of MOBP mRNA in MSA. Most importantly, the identification of MOBP and HIP1 as new constituents of GCIs emphasizes the relevance of these two loci to the pathogenesis of MSA.

Keyphrases

dna methylation
genome wide
total hip arthroplasty
gene expression
signaling pathway
spinal cord injury
copy number
binding protein
spinal cord
hepatitis c virus
hiv infected
essential oil