Treatment intensification strategies after initial metformin therapy in adult patients with type-2 diabetes: results of the DPV and DIVE registries.
Bettina HartmannStefanie LanzingerGesine van MarkFrank Jürgen WoschMesut DurmazMaike PlaumannStefan SziegoleitJochen SeufertReinhard W HollPeter Bramlagenull nullPublished in: Acta diabetologica (2019)
BOT/BOTplus and OAD show good HbA1c reduction even in patients with longer diabetes duration and in older patients. GLP-1 therapy is effective concerning weight loss in overweight patients and is more often used in females and patients with shorter diabetes duration. Interestingly, despite several studies showing positive effects on micro- and macro-vascular outcomes, prevalent macro-vascular diseases are no predictors of GLP-1 use.
Keyphrases
- weight loss
- type diabetes
- glycemic control
- end stage renal disease
- cardiovascular disease
- ejection fraction
- bariatric surgery
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- roux en y gastric bypass
- physical activity
- gastric bypass
- combination therapy
- weight gain
- mesenchymal stem cells
- case control
- obese patients