Dexmedetomidine-induced cardioprotection is mediated by inhibition of high mobility group box-1 and the cholinergic anti-inflammatory pathway in myocardial ischemia-reperfusion injury.
Juan ZhangFan XiaHaifeng ZhaoKe PengHuayue LiuXiaowen MengChen ChenFu-Hai JiPublished in: PloS one (2019)
DEX pretreatment protects against myocardial I/R by inhibiting cardiac HMGB1 production and activating the cholinergic anti-inflammatory pathway.