RGMa Signal in Macrophages Induces Neutrophil-Related Astrocytopathy in NMO.

Shosuke Iwamoto Takahide ItokazuAtsushi SasakiHirotoshi KataokaShinji TanakaTakeshi HirataKeiko MiwaToshihiko SuenagaYoshiki TakaiTatsuro MisuKazuo FujiharaToshihide Yamashita

Published in: Annals of neurology (2022)

RGMa signaling in infiltrated macrophages is a critical driver of neutrophil-related astrocytopathy in NMO lesions, and RGMa-mAb may provide an efficient therapeutic strategy for NMO-associated neuropathic pain and motor deficits in patients with NMO. ANN NEUROL 2022;91:532-547.

Keyphrases

neuropathic pain
spinal cord
spinal cord injury
neural network