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Efficacy of proton therapy in children with high-risk and locally recurrent neuroblastoma.

Alexander F BagleyDavid R GrosshansNancy V PhilipJennifer H FosterMary Frances McAleerSusan L McGovernYasmin Lassen-RamshadAnita MahajanArnold C Paulino
Published in: Pediatric blood & cancer (2019)
Excellent local control was achieved using proton therapy to the primary and post-induction MIBG-positive distant sites. The predominant site of failure is progression in post-induction non-MIBG-avid distant sites. Although proton therapy provides high rates of local control with acceptable toxicity for neuroblastoma, further advances in systemic therapy are needed for the improved control of systemic disease.
Keyphrases
  • lymph node
  • young adults
  • oxidative stress
  • stem cells
  • mesenchymal stem cells
  • bone marrow