Effects of lorazepam on saccadic eye movements: the role of sex, task characteristics and baseline traits.

Ulrich EttingerInga MeyhöferMitul Ashok MehtaVeena KumariPhilip J CorrSteven Cr WilliamsAdam M Perkins

Published in: Journal of psychopharmacology (Oxford, England) (2018)

We conclude that saccadic peak velocity is a sensitive and robust biomarker of benzodiazepine effects. However, lorazepam has pronounced effects also on other parameters of horizontal saccades. Sex-dependent drug effects on spatial consistency may reflect cerebellar mechanisms, given the role of the cerebellum in saccadic spatial accuracy.

Keyphrases

gene expression
genome wide
emergency department
dna methylation