A Smart Fluorescent Probe for NO Detection and Application in Myocardial Fibrosis Imaging.
Tongliang ZhouJunda WangJiamin XuCangxin ZhengYan NiuChao WangFengrong XuLan YuanXin ZhaoLei LiangPing XuPublished in: Analytical chemistry (2020)
On the basis of the pyridazinone scaffold and photoinduced electron transfer (PET) mechanism, we designed a smart nitric oxide (NO) probe, PYSNO, with high sensitivity and selectivity. PYSNO exhibited a rapid response to both exogenous and endogenous NO. This probe can also be used in tracking and investigating NO generation in animal tissue. In the myocardial fibrosis model for mice, PYSNO exhibited a powerful imaging property in vivo as a result of unravelling the progressive relationship between the generation of myocardial NO and the occurrence of myocardial fibrosis.
Keyphrases
- living cells
- fluorescent probe
- left ventricular
- electron transfer
- nitric oxide
- high resolution
- multiple sclerosis
- loop mediated isothermal amplification
- risk assessment
- computed tomography
- quantum dots
- type diabetes
- liver fibrosis
- positron emission tomography
- adipose tissue
- metabolic syndrome
- atrial fibrillation
- structural basis