Tumor CEMIP drives immune evasion of colorectal cancer via MHC-I internalization and degradation.

Biying ZhangJiao LiQingling HuaHaihong WangGuojie XuJiayuan ChenYing ZhuRuiqi LiQing LiangLanqing WangMin JinJing TangZhenyu LinLei ZhaoDejun ZhangDandan YuJinghua RenTao Zhang

Published in: Journal for immunotherapy of cancer (2023)

Overall, our study unveils a novel regulatory mechanism of MHC-I on tumor cell surfaces by CEMIP-mediated internalization and degradation. Furthermore, targeting CEMIP provides an effective strategy for colorectal cancer immunotherapy.

Keyphrases

pseudomonas aeruginosa
biofilm formation
cystic fibrosis
single cell
transcription factor
cancer therapy
stem cells