Astragaloside IV ameliorates radiation-induced senescence via antioxidative mechanism.

Xin LiuShuying ShangWeiwei ChuLiang MaChenxin JiangYanping DingJianlin WangShengxiang ZhangBaoping Shao

Published in: The Journal of pharmacy and pharmacology (2020)

These data suggest that AS-IV can antagonize radiation-induced brain cells senescence; and its mechanism may be related to p53-p21 and p16-RB signalling pathways of ageing regulation.

Keyphrases

radiation induced
radiation therapy
induced apoptosis
dna damage
endothelial cells
cell cycle arrest
stress induced
electronic health record
white matter
resting state
mouse model
anti inflammatory
endoplasmic reticulum stress
oxidative stress
multiple sclerosis
deep learning
cell proliferation
cerebral ischemia