Login / Signup

Ternary BiOI/Bi 2 S 3 /Au Nanosheet Arrays as a Photoelectrochemical Signal Converter for the Detection of Cardiac Troponin I.

Weixuan XuXuelin ZhangShanghua LiuFeng JiangYueyuan LiZhen XuYueyun Li
Published in: Langmuir : the ACS journal of surfaces and colloids (2024)
Nanosheet arrays with stable signal output have become promising photoactive materials for photoelectrochemical (PEC) immunosensors. However, an essential concern is the facile recombination of carriers in one-component nanoarrays, which cannot be readily prevented, ultimately resulting in weak photocurrent signals. In this study, an immunosensor using gold nanoparticle-anchored BiOI/Bi 2 S 3 nanosheet arrays (BiOI/Bi 2 S 3 /Au) as a signal converter was fabricated for sensitive detection of cardiac troponin I (cTnI). The ternary nanosheet arrays were prepared by a simple method in which Bi 2 S 3 was well-coated on the BiOI surface by in situ growth, whereas the addition of Au further improved the photoelectric conversion efficiency and could link more antibodies. The three-dimensional (3D) ordered sheet-like network array structure and BiOI/Bi 2 S 3 /Au ternary nanosheet arrays showed stable and high photoelectric signal output and no significant difference in signals across different batches under visible light excitation. The fabricated immunosensor has a sensitive response to the target detection marker cTnI in a wide linear range of 500 fg/mL to 50 ng/mL, and the detection limit was 32 fg/mL, demonstrating good stability and selectivity. This work not only shows the great application potential of ternary heterojunction arrays in the field of PEC immunosensors but also provides a useful exploration for improving the stability of immunosensors.
Keyphrases
  • sensitive detection
  • visible light
  • loop mediated isothermal amplification
  • quantum dots
  • high density
  • label free
  • reduced graphene oxide
  • real time pcr
  • dna repair
  • oxidative stress
  • highly efficient