Activin A-mediated polarization of cancer-associated fibroblasts and macrophages confers resistance to checkpoint immunotherapy in skin cancer.

Christine Pich-Bavastro Laura Yerly Jeremy Di Domizio Stéphanie R Tissot Michel Gilliet François Kuonen

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Altogether, our data identify the cellular and molecular plasticity of TME and the pivotal role of Activin A in polarizing the TME towards immune suppression and ICI resistance.

Keyphrases

skin cancer
dna damage
electronic health record
oxidative stress
machine learning
artificial intelligence
data analysis