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A genomic ruler to assess oncogenic transition between breast tumor and stroma.

Shubhada DhageAmanda W ErnlundKelly V RugglesDeborah AxelrodRussell BermanDaniel RosesRobert J Schneider
Published in: PloS one (2018)
The dynamics of gene expression in the post-tumor breast stroma likely co-determines disease outcome: reversion to normality or transition to transformation in morphologically normal tissue. Our stromal genomic signature may be important for personalizing surgical and adjuvant therapeutic decisions and risk of recurrence.
Keyphrases
  • gene expression
  • copy number
  • dna methylation
  • early stage
  • bone marrow
  • transcription factor
  • free survival