A genomic ruler to assess oncogenic transition between breast tumor and stroma.
Shubhada DhageAmanda W ErnlundKelly V RugglesDeborah AxelrodRussell BermanDaniel RosesRobert J SchneiderPublished in: PloS one (2018)
The dynamics of gene expression in the post-tumor breast stroma likely co-determines disease outcome: reversion to normality or transition to transformation in morphologically normal tissue. Our stromal genomic signature may be important for personalizing surgical and adjuvant therapeutic decisions and risk of recurrence.