Vascular Disorders of Pregnancy Increase Susceptibility to Neonatal Pulmonary Hypertension in High-Altitude Populations.
Alexandra Heath-FreudenthalLilian Toledo-JaldinInge von AlvenslebenLitzi Lazo-VegaRodrigo MizutaniMargaret E StalkerHussna YasiniFanny MendizabalJesus Dorado MaderaWilliam MundoMelany Castro-MonrroyJulie A HouckAny Moreno-AramayoValquiria Miranda-GarridoEmily J SuDino A GiussaniSteven H AbmanLorna G MooreColleen Glyde JulianPublished in: Hypertension (Dallas, Tex. : 1979) (2022)
The effect of preeclampsia with fetal growth restriction to increase fetal hypoxia and sFlt1 levels may impede normal development of the pulmonary circulation at high altitude, leading to adverse neonatal pulmonary vascular outcomes. Our observations highlight important temporal windows for the prevention of pulmonary vascular disease among babies born to highland residents or those with exaggerated hypoxia in utero or newborn life.