α-Parvin Defines a Specific Integrin Adhesome to Maintain the Glomerular Filtration Barrier.
Manuel RoggJasmin I MaierClara Van WymerschMartin HelmstädterAlena SammarcoMaja LindenmeyerPaulina ZarebaEloi MontanezGerd WalzMartin WernerNicole EndlichThomas BenzingTobias B HuberChristoph SchellPublished in: Journal of the American Society of Nephrology : JASN (2022)
The findings reveal adaptive mechanisms of podocyte integrin adhesion complexes, providing a conceptual framework for therapeutic strategies to prevent podocyte detachment in glomerular disease.