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Evaluation of cell collection efficiency in non-mobilized adult donors for autologous chimeric antigen receptor T-cell manufacturing.

Juan A PiñeyroaJoan CidAlexandru VlageaGloria CarbasséPaola HenaoNoemí BailoValentín Ortiz-MaldonadoNúria Martínez-CibrianMarta EspañolJulio DelgadoÁlvaro Urbano-IspizuaMiguel Lozano
Published in: Vox sanguinis (2022)
The knowledge of the MNC and lymphocyte CE1 of each apheresis device used to collect cells for CAR T therapy, together with the goal of the number of cells required, is essential to define the volume to be processed and to ensure the success of the collection.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • cell therapy
  • healthcare
  • endoplasmic reticulum stress
  • cell death
  • oxidative stress
  • single cell
  • signaling pathway
  • cell proliferation
  • childhood cancer