Language and spatial dysfunction in Alzheimer disease with white matter thorn-shaped astrocytes.
Elisa de Paula França ResendeAmber L NolanCathrine PetersenAlexander J EhrenbergSalvatore SpinaIsabel E AllenHoward J RosenJoel KramerBruce L MillerWilliam W SeeleyMaria Luiza Gorno-TempiniZachary MillerLea T GrinbergPublished in: Neurology (2020)
The negative impact of WM-TSA pathology to language and possibly visuospatial networks suggests that WM-TSA is not as benign as other ARTAG types and may be explored as a framework to understand the mechanisms and impact of astrocytic tau deposition in AD in humans.