Synthesis and characterization of novel ssDNA X-aptamers targeting Growth Hormone Releasing Hormone (GHRH).

Burcu Ayhan-SahinZeynep-Elif ApaydınPınar Obakan-YerlikayaElif-Damla ArisanAjda Çoker Gürkan

Published in: PloS one (2022)

Our results illustrate the synthesis of 24 putative X-aptamers against both GHRH NH2 (1-44) and NH2 (1-29) peptides and TKY1.T1.13, TKY.T2.08, TKY.T2.09 X-aptamers have high serum stability, high target binding potential with low Kd levels.

Keyphrases

growth hormone
nucleic acid
room temperature
cancer therapy
transcription factor
amino acid
human health
metal organic framework