A versatile and accessible polymer coating for functionalizable zwitterionic quantum dots with high DNA grafting efficiency.

Chloé Grazon Margaret Chern Katherine Ward Se Bastien Lecommandoux Mark W Grinstaff Allison M Dennis

Published in: Chemical communications (Cambridge, England) (2019)

Efficient and versatile functionalization of poly(anhydride maleic-alt-isobutylene) (PIMA), with economical commercial reagents, results in the one-step/one-day production of a copper-free click chemistry-ready carboxybetaine-like coating for quantum dots (QDs). The QDs are bright and stable in aqueous media and easily grafted with DNA with >95% efficiency.

Keyphrases

quantum dots
circulating tumor
cell free
sensitive detection
single molecule
energy transfer
nucleic acid
ionic liquid