Wnt-regulated lncRNA discovery enhanced by in vivo identification and CRISPRi functional validation.

Shiyang LiuNathan HarmstonTrudy Lee GlaserYunka WongZheng ZhongBabita MadanDavid M VirshupEnrico Petretto

Published in: Genome medicine (2020)

Our study demonstrates the value of studying lncRNA functions in vivo, provides a valuable resource of lncRNAs regulated by Wnt signaling, and establishes a framework for systematic discovery of functional lncRNAs.

Keyphrases

small molecule
long non coding rna
high throughput
stem cells
long noncoding rna
network analysis
transcription factor
clinical evaluation