Minor role of TP53 and TERT promoter mutations in medullary thyroid carcinoma: report of new cases and revision of the literature.

Roberta CasaliniCristina RomeiRaffaele CiampiTeresa RamoneAlessandro PreteCarla GambaleAntonio MatroneLiborio TorregrossaClara UgoliniRossella Elisei

Published in: Endocrine (2024)

The prevalence of TP53 and TERT promoter mutations is very low in MTC. The reported mutations are pathogenic in the majority of cases. Because of their rarity it is not possible to clarify if they play or not a role in the pathogenesis and/or aggressiveness of this specific thyroid tumor.

Keyphrases

dna methylation
transcription factor
gene expression
total knee arthroplasty
risk factors