SARS-CoV-2 viral genes Nsp6, Nsp8, and M compromise cellular ATP levels to impair survival and function of human pluripotent stem cell-derived cardiomyocytes.

Juli LiuShiyong WuYucheng ZhangCheng WangSheng LiuJun WanLei Yang

Published in: Stem cell research & therapy (2023)

Overall, our findings uncover the extensive damaging effects of Nsp6, Nsp8, and M on hPSC-CMs, underlining the crucial role of ATP homeostasis in CM death and functional abnormalities induced by these SARS-CoV-2 genes, and reveal the potential therapeutic strategies to alleviate these detrimental effects with FDA-approved drugs.

Keyphrases

sars cov
genome wide
respiratory syndrome coronavirus
endothelial cells
dna methylation
genome wide identification
gene expression
genome wide analysis
transcription factor
free survival
risk assessment
climate change
drug administration