Oxycodone pharmacokinetics and fetal exposure after intravenous or epidural administration to the ewe.

Mari Kinnunen Hannu KokkiHeidi HautajärviHeikki HuhtaVeli-Pekka RantaJuha RasanenHanna-Marja VoipioMerja Kokki

Published in: Acta obstetricia et gynecologica Scandinavica (2018)

We determined the pharmacokinetics of oxycodone in pregnant sheep. We showed accumulation of oxymorphone, which an active metabolite of oxycodone, in the fetus. Further studies in human pregnancies are required to evaluate the safety of oxycodone.

Keyphrases

endothelial cells
spinal cord
pregnant women
high dose
preterm birth
gestational age
pregnancy outcomes